SCN2A and epilepsy: The three patients reported were found to be negative for mutational screening in the following epilepsy genes: FOXG1, CDKL5, MECP2, ARX, SCN1A, STXBP1, SLC25A22, PCDH19, SPTAN1, and ARHGEF9. The study showed that SCN2A does not merely act as a disease modifying gene but can independently trigger seizures.