SIRT1 and myocardial infarction: miR-34a, a regulator of age-associated physiology, also suppresses cardiomyocyte proliferation and its inhibition leads to enhanced cardiomyocyte proliferation and improves cardiac function in response to MI through targeting of silent information regulator factor 2 related enzyme 1 (Sirt1), B-cell lymphoma 2 (Bcl2) and Cyclin D1 (Yang et al., 2015).