TNF and obesity due to melanocortin 4 receptor deficiency: The higher hsCRP values in miners could also be explained by the high prevalence of overweight and obesity levels previously described: since obesity (excess adipose tissue) is characterized by a state of permanent mild inflammation with increased circulating levels of inflammatory markers such as hsCRP, IL-6, TNF∝, and others (more detail see Kayser and Verges, 2013).