TNF and hypertensive disorder: Increased levels of IL-6 and TNF-α are detectable in multiple types of hypertension, such as obese hypertension, alcohol-induced hypertension, drug-induced diabetic hypertension, as well as correlative animal models of hypertension, which indicates that inflammatory cytokines such as IL-6 and TNF-α are involved in causing hypertension (Liang et al., 2017; Alanazi and Clark, 2019).