Using a combined in vitro and in silico approach, Xu et al. (2020) showed that SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis, such as TMPRSS2, ADAM metallopeptidase domain 17 (ADAM17), tissue inhibitor of metalloproteinase 3 (TIMP3), angiotensinogen, transforming growth factor beta 1 (TGFB1), connective tissue growth factor (CTGF), vascular endothelial growth factor A (VEGF A), and fibronectin. This evidence concerns the gene CCN2 and pulmonary fibrosis.