Previous studies have found that the overexpression of SIRT1 significantly reduces brain damage in mice with ischemic stroke (Hellberg et al., 2010; Hernandez-Jimenez et al., 2013), probably through anti-inflammation (Wiciński et al., 2018), anti-apoptosis (Yang et al., 2015), anti-oxidation (Lv et al., 2015), regulation of metabolism (Koronowski et al., 2017), and promotion of neural regeneration (Zhao et al., 2015). This evidence concerns the gene SIRT1 and ischemic stroke.