In the colon tissues of CRC mice, crocin down-regulated the phosphorylation of IKK (α/β) (p = 0.000), IκBα (p = 0.000) and NF-κB (p = 0.000) and the expression of DOCK1 (p = 0.000), but up-regulated the expression of UBXN1 (p = 0.000). This evidence concerns the gene DOCK1 and colorectal carcinoma.