TNF and colorectal carcinoma: In CRC mice, 8-weeks crocin administration substantially reduced the concentrations of IL-1β (p < 0.01), IL-6 (p < 0.01), IL-17 (p < 0.05) and TNF-α (p < 0.05) and increased those of IL-15 (p = 0.000) and IFN-α (p = 0.000) in both colon tissues and sera (Table 2).