Pathological stimuli-induced attenuation of endothelial IRS-1/PI3K/AKT/eNOS activation is an important molecular mechanism of endothelial damage, which promotes the incidence of hypertension (Zeng et al., 2000; Perticone et al., 2001; Sironi et al., 2008). The gene discussed is IRS1; the disease is hypertensive disorder.