A recent study revealed that Pellino-1 is an important angiogenic molecule under the control of VEGFR2/Flk-1, as evident in that down regulated Pellino-1 expression during myocardial infarction contributes to suppression of VEGF-mediated angiogenesis via Pellino-1/AKT/eNOS pathway (Thirunavukkarasu et al., 2018). The gene discussed is VEGFA; the disease is myocardial infarction.