It appears that acute myocardial infarction-induced reduction of Pellino-1, an important angiogenic molecule under the control of vascular endothelial growth factor (VEGF) receptor 2/Flk-1, leads to reduced activities of AKT and eNOS (Thirunavukkarasu et al., 2018). The gene discussed is VEGFA; the disease is acute myocardial infarction.