In conclusion, the present study demonstrated that the IAV can induce an exaggerated hypersusceptibility of airway inflammatory response in COPD by activating the lncRNA TUG1/miR-145-5p/NF-κB pathway in vitro, which may associate with the more severe symptoms induced by IAV in COPD. This evidence concerns the gene NFKB1 and chronic obstructive pulmonary disease.