Interfere with the Nrf2 signaling pathway to reduce the expression of NRF2-regulated oxidative enzymes and lead to higher intracellular ROS levels; knocking down NRF2 with bioengineered siRNA agent improves chemosensitivity of cancer cells, which is related to the suppression of NRF2-regulated efflux ABC transporters. The gene discussed is ABCG2; the disease is cancer.