FPAs are hormone-secreting PAs, which result in hyperpituitarism, including acromegaly derived from growth hormone (GH)-secreting PAs, hyperprolactinemia derived from prolactin (PRL)-secreting PAs, and Cushing’s syndrome derived from adrenocorticotropin (ACTH)-secreting PAs. Here, POMC is linked to Cushing syndrome due to macronodular adrenal hyperplasia.