The Nrf2 signaling regulatory system contains at least four components, including Nrf2, Kelch-like ECH-associated protein 1 (Keap1), small musculoaponeurotic fibrosarcoma (Maf), and antioxidant response element (ARE) or electrophile responsive element (EpRE), which in combination are necessary for the antioxidant response (Kwak and Kensler, 2010; Furfaro et al., 2016; de la Vega et al., 2018). This evidence concerns the gene KEAP1 and fibrosarcoma.