CISD2 and pancreatic neoplasm: iv) In pancreatic cancer, one study found that anticancer agent resveratrol enhances the sensitivity of pancreatic cancer cells to gemcitabine via suppressing NAF-1 (nutrient-deprivation autophagy factor-1) expression, inducing ROS accumulation, and activating Nrf2 signaling pathways (Cheng et al., 2018).