KEAP1 and gallbladder cancer: Atypical protein kinase Cι (aPKCι) can promote gallbladder tumorigenesis and chemoresistance of anticancer agent gemcitabine by competing with Nrf2 for binding to Keap1, implying that inhibiting the aPKCι-Keap1-Nrf2 axis might overcome drug resistance for the gallbladder cancer treatment