Whether these results, obtained with a mouse melanoma model, can be translated to immune modulation in a “cold” tumor like PDAC is unclear: the few reports about in vivo administration of P2X7 antagonists (AZ10606120 and A438079) did not analyze the involvement of the immune system (Mohammed et al., 2017) or used immunodeficient nude mice (Giannuzzo et al., 2016). Here, P2RX7 is linked to neoplasm.