TARDBP and amyotrophic lateral sclerosis: The recently elucidated regulation of STMN2 by the known RNA splicing factor TDP-43 suggests that STMN2 may play a critical role in ALS pathophysiology (Klim et al., 2019; Melamed et al., 2019), particularly when TDP-43 pathology is present, making it a strong candidate for therapeutic development (Cook and Petrucelli, 2019).