Reduced STMN2 expression has been reported not only in iPSC derived motor neurons in sALS and familial ALS cases with TDP-43 pathology, but also in motor cortex and spinal motor neurons of fALS and sALS patients with C9orf72 repeat expansions, the most common inherited form of ALS (Melamed et al., 2019). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.