STMN2 and amyotrophic lateral sclerosis: Reduced STMN2 expression has been reported not only in iPSC derived motor neurons in sALS and familial ALS cases with TDP-43 pathology, but also in motor cortex and spinal motor neurons of fALS and sALS patients with C9orf72 repeat expansions, the most common inherited form of ALS (Melamed et al., 2019).