ACAT1 and nervous system disorder: Moreover, in a mouse model for the Niemann-Pick type C disease, a neurological disease caused by primary genetic defects in cholesterol homeostasis, ACAT1 blockade diverts cholesterol from storage to promote more efficient utilization in neural and peripheral tissues, suggesting that targeting ACAT1 is a potential strategy for multiple neurological diseases that involve cholesterol dyshomeostasis (Chang et al., 2020).