Vascular Contributions to Cognitive Impairment and Dementia (VCID): Cognitive impairment or dementia due to acute and/or chronic ischemia, secondary to a stroke, intracranial atherosclerosis, carotid artery stenosis, et cetera or a combination of vascular disease, Alzheimer neuropathologic changes (amyloid/tau), and/or other pathologies. Here, MAPT is linked to Cognitive impairment.