APOE and Alzheimer disease: Cerebral amyloid angiopathy (CAA), the deposition of amyloid aggregates in cerebral vessels, is associated with AD and VCID; moreover, both APOE4 and ICAD are associated with CAA and neurodegeneration (Premkumar et al., 1996; Tian et al., 2004; Yarchoan et al., 2012).