Generally, APOE4 is linked to early memory impairment (Caselli et al., 2007), limbic dysfunction (Wolk and Dickerson, 2010), white matter (WM) ischemia (Koizumi et al., 2018), aberrant lipid metabolism, and neuroinflammation (Liu et al., 2013; Rasmussen, 2016; Tzioras et al., 2019). Here, APOE is linked to ischemia.