While APOE2 is associated with elevated very-low-density lipoprotein (VLDL) and lower dementia risk (Reiman et al., 2020), APOE4 is linked to higher LDL cholesterol (Beilby et al., 2003; Saito et al., 2004; Hall et al., 2006; Bennet et al., 2007) and increased dementia risk. The gene discussed is APOE; the disease is dementia.