Furthermore, monocyte chemotactic protein-1 (MCP-1/CCL2), coupled with its binding receptor CC-chemokine receptor 2, appear crucial mediators of the neuroinflammatory response that drives the disease process in a mouse model of AD (Kiyota et al., 2009, 2013; Bose and Cho, 2013). Here, CCL2 is linked to Alzheimer disease.