AD, first characterized by Alois Alzheimer in 1907 (Alzheimer et al., 1995), presents with widespread brain atrophy, amyloid plaques (large extracellular deposits of amyloid-beta (Aβ) protein aggregates), neurofibrillary tangles (consisting of phosphorylated Tau), neuronal and synapse loss, and dystrophic neurites (Lane et al., 2018). This evidence concerns the gene MAPT and Alzheimer disease.