In addition to roles in AD, mutations in SYNJ1 have been associated with early-onset atypical-Parkinson’s disease, suggesting that SYNJ1 manipulation may also prove beneficial in PD (Drouet and Lesage, 2014; Ben Romdhan et al., 2018; Xie et al., 2019). The gene discussed is SYNJ1; the disease is Parkinson disease.