Finally, many known AD risk genes (e.g., Phospholipase C Gamma 2 (PLCG2), inositol polyphosphate 5-phosphatase D (INPP5D), Phospholipase D3 (PLD3), CD2-associated protein (CD2AP), Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM), Sodium/potassium/calcium exchanger 4 (SLC24A4)) are involved in phospholipid metabolism (Tan et al., 2019; Sims et al., 2020), providing further evidence of the importance of these pathways in disease pathology. This evidence concerns the gene PICALM and Alzheimer disease.