LPAR2 and amyotrophic lateral sclerosis: However, further analysis revealed that the distribution of the muscle fiber according to their size was shifted towards the right in ALS mice deficient for Lpar2. These data indicated that the proportion of fibers with larger diameter was increased in ALS lacking lpar2, whereas SOD1G93ALpar2+/+ animals displayed a greater proportion of small muscle fibers (Figure 7C).