Previous works revealed that LPA2 activation contributes to demyelination after spinal cord injury (Santos-Nogueira et al., 2015; López-Serrano et al., 2019) suggesting that the upregulation of Lpar2 in the peripheral nerves of ALS mice could mediate demyelination and/or damage in motor axons. The gene discussed is LPAR2; the disease is amyotrophic lateral sclerosis.