Despite having previously reported that activation of LPA2 exerts deleterious effects after spinal cord injury (López-Serrano et al., 2019), we observed that the lack of Lpar2 did not modify the number of motoneurons in ALS mice, suggesting that the harmful effects of LPA2 in ALS were independent on motoneuron death. This evidence concerns the gene LPAR2 and amyotrophic lateral sclerosis.