Although microglia and astroglia activation at later stages of the disease was not studied in the present work, the increased microglia reactivity observed in ALS mice deficient in Lpar2 might indicate that this receptor could put the brakes on microglia activation in advanced stages of the disease, which may account for the shorter survival of ALS mice lacking Lpar2. The gene discussed is LPAR2; the disease is amyotrophic lateral sclerosis.