Also, in 2009, Boissonneault et al. confirmed that dysfunctional interaction between miR-328 and BACE1 could be associated to Alzheimer’s disease.; Therefore, this gene plays a vital role in Alzheimer’s disease (Cole and Vassar, 2007; Boissonneault et al., 2009). This evidence concerns the gene BACE1 and early-onset autosomal dominant Alzheimer disease.