These findings indicated that PCOOH evokes LFA-1-mediated cell adhesion to ICAM-1 via actin cytoskeleton organization, and this mechanism is recognized to participate in monocyte adherence to the arterial wall in the initiation of atherosclerosis.73) Furthermore, we investigated the involvement of Rho family GTPases in PCOOH-induced THP-1 cell adhesion to ICAM-1.74) Isoprenoid depletion by fluvastatin and geranylgeranyltransferase inhibition by GGTI-286 suppressed PCOOH-induced cell adhesion to ICAM-1 and F-actin-rich membrane protrusion formation. This evidence concerns the gene ICAM1 and atherosclerosis.