RANKL then stimulates RANK on both luminal and basal epithelial cells to activate NF-κB,43) AKR mouse thymoma (AKT, also known as protein kinase B (PKB))44) and inhibitor of DNA binding 2 (Id2).45) We found that TRAF6-dependent NF-κB activation is crucial for mammary gland development as follows.43). The gene discussed is AKT1; the disease is thymoma.