Treatment with carbonyl cyanide 3-chlorophenylhydrazone (CCCP), a mitochondrial uncoupler, generates more cleaved caspase 1 and mature interleukin-1β (IL-1β) in BRCA1-knockdown cells confirming that BRCA1 deficiency can trigger inflammasome activation and establish a tumor-associated microenvironment that favors cancer progression. The gene discussed is IL1B; the disease is cancer.