Jin et al. reported that metastatic breast cancer cells were able to secrete high levels of ATP that enhances tumor invasion and tumor growth by inducing inflammasome activation in a P2Y purinergic receptor 2 (P2Y2R)-dependent manner, and radiotherapy-resistant-MDA-MB231 cells showed increased inflammasome activation in a P2Y2R-dependent manner [121]. The gene discussed is P2RY2; the disease is breast carcinoma.