It includes seven ligands with pro-inflammatory activity (IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ), as well as anti-inflammatory cytokines (IL-37 and IL-38) [43, 45], having crucial roles in host-defense responses, but also in inflammatory responses that contribute to cancer development [46]. Here, IL18 is linked to cancer.