HDAC6 and non-small cell lung carcinoma: The results of the in-vitro and in-vivo studies demonstrated that the resulting adduct (85) could remarkably inhibit the HDAC6 isoform (IC50 = 4.3 nM) and HSP90 protein (IC50 = 46.8 nM) and could also exert substantial antiproliferative effects against the NSCLC (A549 and H1975).