In a phase 2 trial evaluating the combination of 5-azacytidine and sorafenib in older patients (n = 27) with untreated FLT3-ITD Mutated AML, 78% ORR, 26% CR, 44% Cri/CRp and 7% PR was observed. This evidence concerns the gene FLT3 and acute myeloid leukemia.