The combined sequential action of thrombin, factor XIIIa, and plasmin after tissue restoration results in thrombus degeneration.7,34 This process releases fibrin degradation product (FDP) and D-dimer, which represents the final product of the fibrinolytic system and thus plays a significant role in the clinical evaluation of thrombophilia after major surgical procedures.34 The dynamics of D-dimer on days 1, 2, 5, and 10 are presented in Fig. 2. The gene discussed is F13A1; the disease is thrombophilia.