To characterize these genes, we compared the expression profile of 24 interferon gamma response genes between tumor and normal samples, and presented the results in the heatmap (Figure 1A) and box plots (Figure 1B), which showed that, the expression of 15 interferon gamma response genes was markedly downregulated in tumor samples, including CD69, CD74, CD86, CDKN1A, CIITA, CSF2RB, IL10RA, IRF8, LATS2, LCP2, MT2A, NOD1, PTPN6, SELP, SOD2, while the expression of 9 genes was markedly upregulated in LUAD, including IRF4, ITGB7, NMI, OAS3, PFKP, PNP, RBCK1, RIPK2, and TRAFD1. The gene discussed is IRF4; the disease is neoplasm.