IFN-γ is a key cytokine produced by CD4 T helper cells, CD8 cytotoxic T cells [1, 2], natural killer (NK), natural killer T cells (NKT) cells [3], and, to a less extent, by B cells [4], and professional antigen-presenting cells (APCs) in the tumor microenvironment. This evidence concerns the gene IFNG and neoplasm.