To identify the H3K64 methyltransferases in the malaria parasite, we cloned, expressed, and purified 9 SET (Su (var) 3-9, Enhancer-of-zeste, and Trithorax) domains from P. falciparum as glutathione-S-transferase (GST)-tagged recombinant proteins (Fig. S3, A and B). Here, SET is linked to malaria.