To validate these results, we further examined the ER-stress-related proteins, including BiP, Ero1-Lα, PERK, eIF2α, p-eIF2α, IRE1α, XBP-1 s, and CHOP in colorectal cancer cells treated with different concentrations of DEH for 48 h. The gene discussed is EIF2A; the disease is colorectal cancer.