These findings suit also with the individual of the cohort with DGS, showing low CD4+ naїve T‐cells%, switched memory B‐cells% and IgM levels, along with an inverted CD4+/CD8+ ratio, all biomarkers configuring an immunophenotype associated with autoimmunity, lymphoproliferation and a severe clinical course, characterized in our case by invasive and recurrent infections.23, 24, 25. Here, CD4 is linked to Autoimmunity.