T‐cell phenotype in IEI+ group showed a decrease in CD4+ and CD8+ naїve T‐cells% against an expansion in CD4+ and CD8+ effector memory T‐cells%, being common features of CVID,16 reported also in DGS,17 likely due to persistent immune system stimulation by chronic/recurrent infections. Here, CD4 is linked to common variable immunodeficiency.