Cer is also believed to be a potent activator of the PP2A [46], the ubiquitously expressed serine/threonine phosphatase that plays a key role in many cellular events [30, 31], including cell cycle progression, DNA replication, signal transduction, cell proliferation, and cytoskeleton dynamics [32] and, depending on the cell context, acts either as a tumor suppressor or as a tumor promotional factor [31]. Here, CBLN1 is linked to neoplasm.