In a rare case, inherited zinc deficiency, which is called acrodermatitis enteropathica (AE), is caused by loss-of-function (LOF) mutations of ZIP4 (5, 6), the exclusive high-affinity zinc transporter in gastrointestinal system responsible for zinc uptake from regular diet (7, 8, 9, 10). The gene discussed is TEX11; the disease is acrodermatitis enteropathica.