The KEGG pathway analysis revealed that these ATGs were mainly involved in 3 pathways (Figure S1B), of which platinum drug resistance pathway might play an important role in OSCC treatment strategies 18 and ErbB signalling pathway was relevant to to head and neck squamous cell carcinoma (HNSCC) treatment,19 indicating that these ATGs might provide potential therapeutic targets for OSCC. Here, EGFR is linked to head and neck squamous cell carcinoma.