Tang JY et al20 indicated that ATG5 might be an indicator of overall survival and disease recurrence in OSCC and the high ATG5 expression of was related to high tumour grade, advanced clinical stage, large tumour size and lymph node metastasis of OSCC, indicating that autophagy play a crucial role in OSCC tumorigenesis and progression. The gene discussed is ATG5; the disease is neoplasm.