SHPK1 promotes the autophagy‐linked lysosomal degradation of CDH1/E‐cadherin and then induces epithelial–mesenchymal transition in hepatoma cells, indicating that the blockage of SPHK1 activity to attenuate autophagy may be a promising strategy for the prevention and treatment of hepatocellular carcinoma.29 This evidence concerns the gene CDH1 and hepatocellular carcinoma.