Recently, many studies have reported the emerging effects of PLXND1 in the cardiovascular system27, 35, 36, 37; particularly, a study by Ellie Tzima and colleagues described that PLXND1 functions as an endothelial mechanosensor and regulates vascular function and the site‐specific distribution of atherosclerosis.35 Here, PLXND1 is linked to atherosclerosis.