Recently, Sugie T., et al. reported that PD-L1 expression on tumor cells and on immune cells is significantly correlated with TILs levels and infiltration of CD8 + T cells in TNBC using multiplex fluorescent IHC, which indicated that high level of PD-L1 on IC might reflect T cell-inflamed tumors with the amount of TILs present, including the CD8 + T cells required for anti-tumor responses [37]. Here, CD274 is linked to neoplasm.