rs5935998 and rs4646156 are concordant in their effect on COVID-19 hospitalization (higher ACE2 levels corresponds to higher risk of COVID-19 hospitalization for both) resulting in a strong, positive MR association (MR beta-coefficient: 0.34; 95% CI: 0.17-0.51; P=8.1×10-5). The gene discussed is ACE2; the disease is COVID-19.