The allele frequencies of the TFAP2B polymorphisms associated with an increased incidence of PDA were as follows: rs2817399 (A allele) = 81%; rs987237 (G allele) = 37%; rs760900 (C allele) = 89%; and rs2817416 (C allele) = 25%). Here, TFAP2B is linked to Patent ductus arteriosus.