Rather, we found that MOCCI, WT, and ATGmut-mRNA were also sufficient to lower the secretion of IL-6, MCP-1, and even IL-8 upon challenge with bacterial endotoxin LPS, which was more potent in inducing cytokine secretion in HAECs compared to DENV/ZIKV infections (Fig. 7f). Here, IL6 is linked to Zika virus infectious disease.