As illustrated in Fig. 1, when tumor samples were dichotomized into SOX4 high (top quartile) and low (bottom quartile) expressing subgroups, PI3K signaling was significantly upregulated in both the TCGA (Fig. 1a; p = 3.0 × 10−27) and METABRIC (Fig. 1b; p = 4.7 × 10−70) cohorts in SOX4 high expressing tumors. This evidence concerns the gene SOX4 and neoplasm.