Patient tumor samples from TCGA (n = 1031)3 and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC, n = 1992)36 cohorts were scored for PAM50 subtype37, and PI3K pathway activity was calculated using a previously published PI3K gene expression signature (Supplementary Data 1 and 2)38,39. This evidence concerns the gene PIK3CA and breast carcinoma.