FCGR2B and COVID-19: It should be noted that earlier studies demonstrate that impeding the Fc γ receptor IIb (FcγRIIb, also known as CD32B) blockade caused higher levels of ISGs in dendritic cells and monocytes, whereas inhibiting FcγRIIa altered the outcome of anti-viral response.5 Consistent with this observation, Combes et al.1 found that blocking FcγRIIb rather than blocking antibodies to CD16 or CD64 rescued the induction of ISGs in monocytes cultured with the sera from patients with severe COVID-19.