The results indicated that WBP2 was localized in the cytoplasm of lung cancer cells, whereas with regard to expression, WBP2 was poorly or even negatively expressed in normal cells (71.9%, 23/32) (low expression in normal bronchial epithelial cells, negative expression in normal alveolar epithelium), but highly expressed in lung adenocarcinoma and squamous cell carcinoma (55.2%, 70/127, Fig. 1A, Supplementary Fig. S1). This evidence concerns the gene WBP2 and squamous cell carcinoma.