NGFR and Alzheimer disease: The latter appears to be the profound functional effect caused by the deletion of p75NTR signaling since a more synchronized FSN activity leads to the rescue of gamma oscillations during sharp waves ripples, decreases Aβ load, and induces a turnover of microglia from a pro-inflammatory phenotype towards a phagocytic state in the 5XFAD AD mouse model in vivo48.