Inefficient microtubule-based transport in axons is linked with several age-related neurodegenerative diseases including Alzheimer’s, Huntington’s disease, and hereditary spastic paraplegia (35), as well as with ALS caused by mutations in SOD1, TARDBP, and FUS (35, 46, 47). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.