Zhang et al. [65] found that METTL3 relied on IGF2BP1 to stabilize chromo box 8 (CBX8) mRNA which can inhibit the chemosensitivity and maintain the stemness of colon cancer (CC) by promoting the expression of leucine rich repeat containing G protein-coupled receptor 5 (LGR5). Here, LGR5 is linked to malignant colon neoplasm.