IGF2BP2 and colorectal carcinoma: Li et al. [60] found that METTL3, as an oncogene, can extend the half-life of sex determining region Y-box 2 (SOX2) mRNA relied on IGF2BP2 to maintain the expression of SOX2 and SOX2 target genes (CCND1, MYC and so on), which further promotes CRC progression.