METTL3 and colorectal carcinoma: Additionally, METTL3 was reported to be directly interacted with the 5′/3′UTR regions of Hexokinase 2 (HK2) mRNA relied on IGF2BP2/3, the 3′UTR region of Glucose transporter 1 (GLUT1) mRNA relied on IGF2BP2, stabilized them and then further activated the glycolysis pathway to induce CRC tumorigenesis [63].