The importance of the innate immune response is also reflected in the treatment of oligoarticular JIA, where the most commonly used drugs are either non-specific or target important components of the innate immune system such as tumor necrosis factor alpha (TNFα) and interleukin 6 (IL-6), while therapies targeting T and B cells in the adaptive immune system are more seldom used [10, 11]. This evidence concerns the gene TNF and oligoarticular juvenile idiopathic arthritis.