RIPK3 and heart failure: In addition, the evidence from studies into necroptosis and MI pathologies indicated that the inhibition or ablation of necroptotic markers including RIPK3 provided beneficial effects in RIPK3 knockout (RIPK3−/−) mice as well as RIPK3 knockdown (RIPK3−/+) mice via the amelioration of the MI-induced cardiac remodeling and dysfunction as well as in heart failure [21, 33].