By comparing with these 65 mRNAs, RSPO3 (ENSG00000146374.12) and SFRP4 (ENSG00000106483.10) in matrix CML(0.7) were found to be related to the occurrence of colon cancer. The gene discussed is SFRP4; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.