F2 and blood coagulation disease: Subgroup 1 (Fig. 1) was subjected to high cardiovascular and respiratory dysfunction marked by low to decreasing heart rate, blood pressure and temperature and a high fraction of inspired O2 (FiO2), while incurring low organ dysfunction, inflammation and coagulopathy, as indicted by high platelet counts, hematocrit and hemoglobin levels, and a low international normalized ratio (INR) and partial prothrombin time (PTT).