As the production of IL-17A production from naïve splenocytes stimulated with PMA/ionomycin was also suppressed by MabE (Supplementary Figure 3) and there was no change in CD4+ T cells in MabE-treated mice (data not shown), MabE may exert its anti-inflammatory effects in IMQ-treated mice partly through the suppression of γδT17 cell activation and their IL-17A production to attenuate psoriasis-like inflammation. The gene discussed is CD4; the disease is psoriasis.