CD4 and nonpapillary renal cell carcinoma: As displayed in Fig. 10a-i, nine out of 21 TIICs (T cells CD4 memory activated, Plasma cells, T cells gamma delta, T cells regulatory (Tregs), Macrophages M0, Monocytes, Macrophages M1, Mast cells resting, Dendritic cells resting) were highly associated with high- and low- risk ccRCC patients stratified by our established riskScore (all P < 0.05).