In the occurrence and development of CRC, some evidences and theories have been obtained among some of them, such as FAT4, PTCH1, ROS1, PIK3R1, CREBBP, FLT4, EP300 and PDGFRA, and many unanswered and unknown questions are to be discovered [21–25]. The gene discussed is CREBBP; the disease is colorectal carcinoma.