Taken together, we screened 11 genes (TP53, APC, KRAS, BRAF, ATM, PIK3CA, FAT4, FMN2, TRRAP, LRP1B and ROS1) associated with diagnose, pathological classification, tumor stage and survival of CRC, and mutation detection of these genes can be applicable in the clinic of CRC. Here, PIK3CA is linked to colorectal carcinoma.