Correspondingly, exclusion of the literature [65] with the largest deviation for the APOE ε4 allele resulted in conclusions consistent with those originally recorded, following recalculation, and so carrying the ε4 allele can be considered a risk factor for hyperlipidemia (OR = 1.657, 95% CI = 1.365–2.012, P < 0.001). This evidence concerns the gene APOE and hyperlipidemia.