A meta-analysis was conducted to explore the relationship between APOA (A1-75bp, A1 + 83 bp, A5–1131T>C), APOB (MspI, XbaI, EcorI), and APOE with hyperlipidemia so that an evidence-base can be provided for the prevention and control of hyperlipidemia. The gene discussed is APOE; the disease is hyperlipidemia.