In summary, the results of the present meta-analysis revealed that the C allele of APOA5 1131 T > C, the A allele at APOA1-75 bp, the APOB XbaI T allele, and the ε2 and ε4 alleles of APOE may represent genetic risk factors for susceptibility for hyperlipidemia. The gene discussed is APOE; the disease is hyperlipidemia.