This study demonstrated that serum HMGB1, TNF-α, and IL-6 levels in the Q group were significantly lower than those in the C group 1 and 3 days after surgery, indicating that QLB analgesia combined with general anesthesia for laparoscopic radical gastrectomy can significantly inhibit the systemic inflammatory response and subsequently alleviate cognitive decline. Here, IL6 is linked to Mental deterioration.