ERBB2 and neoplasm: Moreover, Sato et al. (Sato et al., 2015b) have also reported that a single dose of anti-HER2 NIR-PIT (100 J/cm2 of NIR-light 24 h after the injection of 100 μg of trastuzumab-IR700) using a HER2-positive (3T3/HER2-luc-GFP) mouse model of lung metastases was sufficient to cause a significant reduction in the volume of tumour metastasis in vivo. However, multiple NIR-PIT exposures (100 μg of trastuzumab-IR700 on day 13, 15, 17 and 19 followed by 100 J/cm2 NIR-light 24 h post each APC injection) were required to improve the overall mouse survival.