Moreover, a dramatic decrease in tumour volume and a significant increase in survival were reported in mice bearing orthotopic CD133-positive GBM xenografts trans-cranially irradiated with 50 J/cm2 (on day 1) and 100 J/cm2 (on day 3) of NIR-light after the administration of 100 μg of AC133-IR700. Here, PROM1 is linked to neoplasm.