NFKB1 and fungal infectious disease: Interestingly, however, we find several AMP and IM genes that normally are upregulated in NF-kB-dependent way upon bacterial and fungal infections including the fly microbiota (Broderick et al. 2014; Kounatidis et al. 2017), to be downregulated following FHV infection at both 24- and 48 h p.i., even in aged flies.